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Attenello, F.J., Tuchman, A., Christian, E.A., Wen, T., Chang, K.E., Nallapa, S., et al. (2016) Infection Rate Correlated with Time to Repair of Open Neural Tube Defects (Myelomeningoceles): An Institutional and National Study. Child’s Nervous System, 32, 1675-1681.
https://doi.org/10.1007/s00381-016-3165-4

has been cited by the following article:

• TITLE: The Timing of Primary Neurosurgical Repair and Wound-Site Infection in Children with Myelomeningocele

  AUTHORS: Joseph O. Obande, Paul T. Bitrus, Elizabeth I. Obande

  KEYWORDS: Spina Bifida, Surgical Timing, Excision and Repair, Surgical Site Infection, Myelomeningocele

  JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.14 No.2, April 18, 2024

  ABSTRACT: Background: The optimal time to closure of a newborn with a myelomeningocele has been the focus of a number of evaluations. The Timing of primary surgery has received significant attention due to its relationship to repair-site infection that can lead to increased morbidity and prolonged hospital stays. It is on this basis that recommendations have utilized 48 - 72 hours post birth as ideal time of closure. This is not only prevent infection at the site but also prevent ventriculitis and neural structure damage. We therefore, hypothesized an increase in wound infection rates in those patients with delays in myelomeningocele repair. Methods: We retrospectively reviewed the records of 103 children with myelomeningocele treated between 2016 and 2023. At discharge the patients were followed up at the post-operative clinic visit 2 weeks later. Children were assigned to 1 of 2 groups, those who underwent primary neurosurgical repair within 72 hours of delivery (Group 1) and those undergoing repair after 72 hours (Group 2). We compared the infection rates. Results: 103 children who underwent myelomeningocele repair were identified, with a median time from birth to treatment of 1 day. Eight (7.8 %) patients were noted to have post-repair surgical site complications. There was no significant difference in rates of infection between Group 1 and Group 2 repair times. The presence of infection was associated increased length of stay when compared to neonates without infection. Conclusion: In children with myelomeningocele, the timing of primary neurosurgical repair appears not to have a significant impact on surgical site infection. Closure of the spinal lesion within the first 72 hours of life may be more favorable for neural damage prevention. These results suggest that early myelomeningocele repair may not impart significantly on the rate of wound-site infection.