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Chen, X., Zhang, M., Gan, H., Wang, H., Lee, J.H., Fang, D., Kitange, G.J., He, L., Hu, Z., Parney, I.F., et al. (2018) A Novel Enhancer Regulates MGMT Expression and Promotes Temozolomide Resistance in Glioblastoma. Nature Communications, 9, Article 2949.
https://doi.org/10.1038/s41467-018-05373-4

has been cited by the following article:

• TITLE: Brain Urea as a Potential Biomarker of Neoplasm Progression

  AUTHORS: Larisa Mikhailovna Obukhova, Elena Ivanovna Erlykina, Igor Aleksandrovich Medyanik, Artem Sergeevich Grishin, Angelina Mikhailovna Shutova

  KEYWORDS: Glioma, Peritumoral Zone, Urea, Gliomal Molecular Genetic Markers, Ki-67, MGMT

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.12 No.4, April 3, 2024

  ABSTRACT: Metabolic reprogramming is a key feature driving oncogenesis in cancers. Recent studies have revealed that protein metabolism is largely altered in gliomas facilitating its malignant growth. Urea is the end product of nitrogen metabolism which is mainly produced by arginase. The interdependence of arginase and other biochemical mechanisms triggered scientific research interest. This research aimed to investigate the relationships between the urea as the main parameter of protein metabolism and glioma progression. It was also the most pronounced relationship between urea and the level of the nuclear protein Ki-67 as a marker of proliferative activity and O-6-methylguanine-DNA methyltransferase (MGMT), which performs DNA repair. Postoperative material from 20 patients with gliomas of different grades of anaplasia was analyzed.