TITLE:
Acute Coronary Syndrome of Young Subjects at the Luxembourg Mother-Child University Hospital in Bamako
AUTHORS:
Mamadou Toure, Mariam Dagnogo, Massama Konate, Mariam Sako, Daouda Fofana, Hamma Sankare, Almou A. Diall, Modibo Doumbia, Baba I. Diarr, Mady Sow, Abdoul Wahhab Terra, Coumba A. Thiam, Boubacar Sonfo, Boubacar Diarra, Asmaou Keita, Ousmane Traore, Hamidou O. Ba, Ichaka Menta
KEYWORDS:
Acute Coronary Syndrome, Young Subjects, Coronary Angiography, CHU Luxembourg, Bamako
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.14 No.3,
March
29,
2024
ABSTRACT: Introduction: Acute coronary syndrome is often the first event of coronary disease of young subjects. Objective: To study sociodemographic, clinical, paraclinical, therapeutic and evolutionary aspects of acute coronary syndrome of young subjects. Patients and Methods: Descriptive cross-sectional study with prospective recruitment from October 01, 2020 to March 31, 2022. Were included all patients admitted for acute coronary syndrome whose age was less or equal to 45 years and who had undergone coronary angiography at the Mother-Child University Hospital on Luxembourg from Bamako. Results: During the study period, we collected 60 patient files out of 198. These 60 patient files met our inclusion criteria. Hospital frequency was 30.30%. Average age of patients was 40.43 ± 3.9 years. Sex ratio M/F was 5.3. Main cardiovascular risk factor was smoking tobacco (23.42%), followed by dyslipidemia (13.92%). Functional signs were dominated by angina 62% followed by dyspnea 25.3%. Persistent ST-segment elevation on electrocardiogram was present in 76.4%. Left ventricular systolic dysfunction was present in 26.5%. Time to first medical contact was more than 12 hours in 62.7% of cases. Radial approach was adopted in 94% of cases. Coronary angiography was pathological in 85% (n = 51) of cases. Lesions were single-vessel disease in 47.1% and culprit artery was anterior interventricular in 51% of cases. Dual anti-platelet aggregation was aspirin and ticagrelor in 91.8% of cases. Angioplasty was performed in all patients who had significant abnormalities at coronary angiography. In-hospital mortality was 3.9%. Conclusion: Acute coronary syndromes exist in young Africans with a male predominance. Main cardiovascular risk factor is smoking tobacco. Coronary lesions are single vessel disease in the majority of case. Most of patients meet medical team after 12 hours. Time to first medical contact is a main challenge in our country.