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Müller, W.E., Maidhof, A., Zahn, R.K., Schröder, H.C., Gasić, M.J., Heidemann, D., Bernd, A., Kurelec, B., Eich, E. and Seibert, G. (1985) Potent Antileukemic Activity of the Novel Cytostatic Agent Avarone and Its Analogues in Vitro and in Vivo. Cancer Research, 45, 4822-4826.

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• TITLE: Steroids, Tri- and Meroterpenoids with a Quinone Structure—A Review

  AUTHORS: Maryam S. M. Aghaei, Thies Thiemann

  KEYWORDS: Steroid, Secosteroid, Meroterpenoid, Triterpenoid, Quinone, Anti-Tumour Agent, Antibiotic, Natural Product

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.14 No.1, March 29, 2024

  ABSTRACT: Terpenoids with quinoid structures are found as natural products. This includes steroidal quinones, quinones with a secosteroid structure and meroterpenoid quinones. Importantly, catechol estrogens as endogenous metabolites of estradiol and estrone are precursors of reactive quinones and semiquinones, which are thought to contribute to estrogen-induced carcinogenesis. On the other hand, a number of quinones that include substituted naphthoquinones and anthraquinones are highly cytotoxic and have been used in cancer treatment. This makes the structures interesting synthetic targets. The following is a review of important natural and synthetic terpenoid and steroid quinone hybrids.