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Y. L. Janin, A. M. Aubertin, A. Chiaroni, C. Riche, C. Monneret, E. Bisagani and D. S. Grierson, “Imidazo (1,5-G)(1,4)diazepines, TIBO Analogues Lacking the Phenyl Ring: Synthesis and Evaluation as Anti-HIV Agents,” Tetrahedron, Vol. 52, No. 48, 1996, pp. 15157-15170.

has been cited by the following article:

• TITLE: Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents

  AUTHORS: Simin Teimoori, Kuppusamy Panjamurthy, Kambappa Vinaya, Doddakunche S. Prasanna, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

  KEYWORDS: Cancer Therapy, Cytotoxicity, 1, 4-Diazepane, Isocyanates, Isothiocyanates

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.4, October 12, 2011

  ABSTRACT: In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide / carbothioamide)-1,4-diazepane derivatives were designed, synthesized and characterized using 1H NMR, LCMS and elemental analysis. These molecules were evaluated for their anti-cancer activity by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on B-cell leukemic cell line, Reh. Carboxamide moiety containing derivatives showed good activity compared to the corresponding carbothioamide derivatives. In particular, 4-benzhydryl-N-(3-chlorophenyl)-1,4-diazepane-1-carboxamide showed good activity with IC50 value of 18 µM.