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Y. Hirokawa, I. Fujiwara, K. Suzuki, H. Harada, T. Yoshikawa, N. Yoshida, and S. Kato, “Synthesis and Structure-Affinity Relationships of Novel N-(1-Ethyl-4-methyl-hexahdro-1,4-diazepiN-6-yl)pyridine-3-carboxamides with Potent Serotonin 5-HT3 and Dopamine D2 Receptor Antagonistic Activity,” Journal of Medicinal Chemistry, Vol. 46, 2003, pp. 702-715. doi:10.1021/jm020270n

has been cited by the following article:

• TITLE: Synthesis and Biological Evaluation of Novel Homopiperazine Derivatives as Anticancer Agents

  AUTHORS: Simin Teimoori, Kuppusamy Panjamurthy, Kambappa Vinaya, Doddakunche S. Prasanna, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

  KEYWORDS: Cancer Therapy, Cytotoxicity, 1, 4-Diazepane, Isocyanates, Isothiocyanates

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.4, October 12, 2011

  ABSTRACT: In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide / carbothioamide)-1,4-diazepane derivatives were designed, synthesized and characterized using 1H NMR, LCMS and elemental analysis. These molecules were evaluated for their anti-cancer activity by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on B-cell leukemic cell line, Reh. Carboxamide moiety containing derivatives showed good activity compared to the corresponding carbothioamide derivatives. In particular, 4-benzhydryl-N-(3-chlorophenyl)-1,4-diazepane-1-carboxamide showed good activity with IC50 value of 18 µM.