TITLE:
Serological Profile of Hepatitis D Virus (Hepatitis Delta) in the Hepato-Gastro-Enterology Department of Chu Gabriel Toure
AUTHORS:
Sanra Déborah Sanogo, Kadiatou Doumbia, Hourouma Sow, Moussa Younoussou Dicko, Youssouf Oumarou, Abdoulaye Berthé, Sabine Drabo, Luc Sidibé, Makan Siré Tounkara, Abdoulaye Maiga, Ouatou Mallé, Ganda Soumaré, Anselme Konaté, Moussa Tièmoko Diarra
KEYWORDS:
HBsAg, VHD RNA, Liver Disease
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.14 No.3,
March
28,
2024
ABSTRACT: Infection with the defective hepatitis D virus (HDV) co-infects or superinfects a patient carrying hepatitis B virus (HBV). Delta virus infection is relatively common. The seriousness of infection with the hepatitis D virus (HDV), a virus defective in a patient carrying the hepatitis B virus (HBV), lies in its aggravating effect on the associated viral hepatitis B. Our aim was to study the serological profile of HDV in HBsAg-positive patients. As this study was fragmentary, we initiated this study with the aim of investigating the serological profile of HDV in HBsAg-positive patients. This was a descriptive and analytical cross-sectional study that ran from March 2019 to February 2020, a 12-month period. It focused on the population of patients seen and screened positive for HBsAg. We obtained a frequency of 10%. The mean age of our patients was 41.8 ± 13.09 years. The sex ratio was 4.5. VHD RNA was detected in 50% of patients. In 100% of cases, the presence of VHD RNA was associated with advanced fibrosis according to the APRI score, but without any statistically significant link. All HBV-infected patients should be screened for anti-HDV Ac. HDV infection leads to rapid progression to complications of liver disease.