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P. O’Reilly, L. Martin and G. Collins, “Few Patients with Prostate Cancer Are Willing to be Randomised to Treatment,” British Medical Journal, Vol. 318, 1999, p. 1556.

has been cited by the following article:

• TITLE: Quality of Life in Men Treated for Early Prostate Cancer: A Prospective Patient Preference Cohort Study

  AUTHORS: Carmel Nirupa Anandadas, Susan Elizabeth Davidson, Noel William Clarke, Stephen Charles William Brown, John Paul Logue, Lynne Gilmore, Richard Swindell, Gerald Nicholas Collins, Patrick Henry O’Reilly, Guy David Wemyss-Holden, Maurice Waiming Lau, Pradip Madhukar Javle, Vijay Alini Chandi Ramani, Richard James Brough, James Pinson Wylie, Richard Andrew Cowan

  KEYWORDS: Early Prostate Cancer, Quality of Life, Patient Preference, Prostatectomy, Hypo-Fractionated Radiotherapy, Brachytherapy

  JOURNAL NAME: Journal of Cancer Therapy, Vol.2 No.4, October 12, 2011

  ABSTRACT: Objectives: In 1997, a study was launched to investigate the treatment of early prostate cancer. Using a patient preference design, health-related quality-of-life (HRQOL) and disease specific HRQOL was assessed prospectively to compare men undergoing radical prostatectomy (RP), hypo-fractionated conformal radiotherapy (CRT) or brachytherapy (BT). Methods: Patients with localised prostate cancer were counselled by a urological surgeon, clinical oncologist and specialist uro-oncology nurse. Patients received treatment according to individual preference. 430 men chose and received RP (n = 217), CRT (n = 161) and BT (n = 52). 354 (82%) completed pre-treatment RAND 36-Item Short-Form Health survey version-2 (SF36v2) and University of California, Los Angeles Prostate cancer index (UCLA-PCI) questionnaires. HRQOL score changes from baseline to 24 months were compared using Kruskall-Wallis test. Results: Pre-treatment, the CRT cohort scored lower for physical function (p = 0.0029) and general health perception (p = 0.0021). The BT cohort reported better baseline scores for urinary function (p = 0.0291), urinary bother (p = 0.0030), sexual function (p = 0.0009) and bowel bother (p = 0.0063). At 24 months, bowel function was similar for CRT and BT but both modalities were worse than RP (p = 0.0010). Urinary continence deteriorated most following RP (p