TITLE:
Profile of Autoantibodies and Clinical Symptoms in Guinean Patients with Connective Tissue Diseases
AUTHORS:
Mariama Sadjo Diallo, Doufin Traore, Adame Diouf, Djiba Kaba, Issiaga Diallo, Doudou Georges Massar Niang, Alimou Camara, Oumar Mouctar Diallo, Boh Fanta Diane, Abdoulaye Barry, Ouo-Ouo Yaramon Kolie, Moustapha Mbow, Aly Badra Kamissoko, Djibril Sylla, Babacar Mbengue, Mohamed Cisse
KEYWORDS:
Autoantibodies, Extractible Nuclear Antigen (ENA), Connective Tissue Diseases, ELISA
JOURNAL NAME:
Open Journal of Immunology,
Vol.14 No.1,
March
25,
2024
ABSTRACT: Connective tissue diseases (CTDs)
are Autoimmune diseases (AIDs) characterized by the appearance of
autoantibodies, which are diagnostic markers. Investigations of these
autoantibodies play a major role in the management of several autoimmune
diseases. The objective of this study was to describe the profile of anti-ENA
antibodies according to the clinical symptoms of mixed CTDs in Conakry teaching
Hospital. We performed a cross-sectional study during six months. A total of 20
patients was recruited and we measured antibodies using the ELISA technique. The
mean age of our patients was 36.5 years, with a predominance of females.
Cutaneous and rheumatological signs were the main clinical manifestations. SLP
was the most frequent CTDs; the threshold of ENA antibodies positivity was
higher in scleroderma with and SLP. Anti-ENA identification reveals the
frequency of anti-SSA (83.33%), anti-U1RNP (66.66%) and anti-histone (50%)
antibodies. Antinuclear antibodies (ANA) react with various components of the
cell nucleus. Their detection is of major interest in the diagnosis of CTDs.
Our results highlight the importance of determining the specificity of these
antibodies to guide differential diagnosis.