TITLE:
Deciphering the Hidden Secrets between the Early Skin Wrinkling & the Metabolic (X) Syndrome with the Possible Reversal of This Process at the Molecular Level
AUTHORS:
Dalal Alsaadoun
KEYWORDS:
Collagen, Skin Wrinkling, Glycation, Hyper-Insulinemia, Hidden Obesity, Vis-ceral Fat, Inflammatory Cytokines
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.14 No.1,
March
21,
2024
ABSTRACT: The
aging process is a group of degenerative changes that physiologically occur in
most of the people in the elderly. This affects one or more of the human body
systems. The treatment of diseases related to the aging process has a huge
impact on the economy of all nations. Aging of the skin comes on the top and
despite that, the results of the already present lines of treatment are not
always satisfactory. This acts as a stimulus for us to dig deeper to discover
the root causes of the premature aging of the skin. This was simply caused by
the accumulation of repeated minute
damage to the internal structure skin. In other words, if the degree of
minute damage is more than the capacity of the skin to repair, the repeated
micro-damage is presented in the long run as a skin wrinkling. Moreover, the
skin acts as a mirror that reflects
the internal structures of the human body. Thus, the more degenerative changes
in the human body systems, the more the skin could become wrinkled. Our
strategy to prevent or at least slow down the aging process of the skin depends
on 2 main steps; the 1st is to reduce the micro-damage as can as
possible, and the 2nd is to enhance the capacity of tissue
regeneration to be able to reverse the already present damaged skin. As the 2
processes are synchronized with each other, this strategy would be considered
the ideal for prevention of skin wrinkling especially premature ones. This not
only reverses premature skin wrinkling but also protects it from future
wrinklings. This review sharply pointed out the role of the functional collagen of the dermal layer
of the skin in the prevention of skin wrinklings. Therefore, it would be the
target to study how collagen works in the complex machinery of the dermal layer
of the skin. This concept deeply believes that the recovery of dermal collagen
has a much better effect than simply ingesting collagen or receiving a topical
collagen booster.