TITLE:
Re-Densification Effect of Pressure-Injected Peptide-Hyaluronic Acid Combination on Male Androgenic Alopecia
AUTHORS:
Pablo Naranjo, Yuri Vinshtok
KEYWORDS:
Jet Injections, Electronic Pneumatic Injections, Male Androgenic Alopecia, Bioactive Peptides, EnerJet
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.14 No.1,
March
21,
2024
ABSTRACT: Introduction: Mechanism of male androgenic alopecia (MAGA) is
complex and leads to an excessive hair shedding and decreased hair density.
Oral, topical, and injectable autologous treatments demonstrate ability to
stimulate hair re-growth, but the response is suboptimal or plateaus off.
Synthetic combination of the peptide complex and hyaluronic acid (P-HA)
demonstrated hair regrowth in alopecia patients. Electronically-operated
pneumatic injections (EPI) generate micro-trauma in the dermis and under
wound-healing conditions may enhance regeneration effect of P-HA. Methods: Subjects seeking
improvement of their male pattern hair loss (Hamilton-Norwood type 2-4) received the P-HA treatments through EPI. The
course included 4 treatments every two weeks over the 8-week period. In 6
months, the hair growth was assessed comparative to baseline by global clinical
photography and digital phototrichograms. The treatment safety and tolerability
were documented through the whole study period. Results: Twelve men (30-45
years old) completed the treatment course with high tolerability and without
adverse events. Post-treatment assessment of the previously bald areas showed
improved coverage on the clinical photographs. The phototrichograms
demonstrated statistically significant increase in terminal hair density by
36%, cumulative hair thickness by 37%, and follicular units by 20%; all
contributing to a 38% increase in cumulated hair density (all p Conclusion: Electronic pneumatic
injections are well
tolerated and can be safely used for the needle-free administration of the
peptide-hyaluronic acid combination in MAGA therapy. We achieved significant
hair re-densification in the balding scalp. The exact role of the EPI-induced
impact in the hair re-growth mechanism remains to be ascertained.