TITLE:
The Protective Effect of Moringa oleifera Leaves Extract on Paracetamol Hepatotoxicity in Male Rats
AUTHORS:
Reham M. Al-Sultan, Noorah Saleh Al-Sowayan
KEYWORDS:
Moringa oleifera, Paracetamol, Hepatotoxicity, Oxidative Stress
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.17 No.3,
March
20,
2024
ABSTRACT: In recent years, there has been an increase
in concern regarding the effects of paracetamol poisoning on liver tissues,
particularly when consumed in large amounts. Some studies have estimated that
paracetamol is involved in 56% of acute liver diseases, whereas 0.4% of
paracetamol overdose cases result in fatal-ity. In this study, the effects of
Moringa oleifera on paracetamol toxicity in the liver were explored. It has
been demonstrated that Moringa oleifera is highly nu-tritious, contains
bioactive molecules, and is therapeutically beneficial. Many studies have shown
that Moringa oleifera leaves possess a wide range of biologi-cal properties,
including antioxidant, tissue protection, analgesic, antihyperten-sive, and
immunomodulatory activities. This study highlights the protective role of
Moringa oleifera on handling possible paracetamol hepatotoxicity in male rats.