TITLE:
Carpel Tunnel Syndrome: A Link with Vitamin D, Body Mass Index and Hyperlipidemia
AUTHORS:
Faten Abdulhady Zakaria, Thamer Abdullah Alsufayan, Musaad Bedah Alsahly
KEYWORDS:
Carpal Tunnel Syndrome, Vitamin D, Body Mass Index
JOURNAL NAME:
Neuroscience and Medicine,
Vol.15 No.1,
March
18,
2024
ABSTRACT: Introduction: Carbai tunnel syndrome [CTS] is compression of the median nerve at the wrist
, this causes tingling in the hands, pain, numbness, tingling in the fingers particularly
the thumb, index and middle fingers, loss of sensation in the hands and fingers, also weakness
in the hands. The aim
of the present study was to study a possible association which could be
found between electrophysiological data in CTS, BMI, hyperlipidemia, and vitamin
D [Vit D]
levels. Methods: We used a sample of 40 females
of the same age group, who were divided into Group 1 as a control consists of 18 healthy females and
Group II consisted of 22 age matched females with clinical and electrophysiological
evidence of CTS. We measured atherogenic index [AI] as a marker of hyperlipidemia, body mass index [BMI], Vit D status and electrophysiological
tests of CTS. Results: Subjects with CTS had deficient Vit D status, they had significantly high atherogenic index (AI), and significant high
BMI all compared to control Group I. Median sensory conduction velocity was significantly
correlated negatively with BMI and atherogenic index, and positively correlated
significantly with Vit D status. But median sensory
and motor action potential latency were significantly correlated positively with
BMI and atherogenic index, and negatively correlated significantly with Vit D status
The analysis revealed BMI, atherogenic index and Vit D status as predictors of median
nerve sensory and motor action potential latency and sensory nerve conduction velocity
in CTS. Conclusion: The results of this study suggest that obesity and hyperlipidemia are potent
CTS risk factors and declared the direct association between Vit D status and CTS
occurrence. Our study supports the notion
of the compensatory neuroprotective role of Vit D which could have a direct impact
on the nerves integrity as it has an anti-inflammatory property which acts in relieving nervous insults
and stress.