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Vasil’ev, N., Romanov, D. Ivanovskaya, N. and Osin, N. (2005) Complexing Dibenzene-Containing Five-Membered Cyclic Compounds Containing Two Symmetrical beta-Dicarbonyl Substituents with Fluorinated Radicals. RU Patent No. 2296756.

has been cited by the following article:

• TITLE: 3,6-Bis-β-Dicarbonylsubstituted Carbazoles Bearing N-Spacers and Their Eu(III) Complexes as Immunofluorescent Labelling Agents

  AUTHORS: Dmitry E. Pugachev, Georgy V. Zatonsky, Tatyana S. Kostryukova, Anna G. Shubina, Nikolay V. Vasiliev

  KEYWORDS: Fluorescence Immunoassay, Fluorinated β-Diketones, Carbazole, Europium Complexes, Streptavidin, Nanodispersions

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.14 No.1, March 15, 2024

  ABSTRACT: New reagents for immunofluorescence analysis of carbazole series containing fluorinated β-dicarbonyl fragments and carboxylic substituent groups separated by spacers of different lengths from the light-gathering carbazole scaffold have been developed. The markers in complex with Eu3+ ions possess stability in the aqueous phase, intense and prolonged luminescence (τ 550 - 570 μs) with characteristic emission maxima in the region of 615 nm and excitation wavelengths in the region of 380 - 390 nm, which distinguishes them from most of the analogs used. In the study of marker conjugation with streptavidin, a reagent containing 4 - 5 europium labeling complexes based on spacer-containing carbazole tetraketone was obtained. The marker-doped silicate nanoparticles exhibit intense and long-lived luminescence in the characteristic region.