TITLE:
A Comprehensive Review of Exosomes with Therapeutic Potential in Cancer and Coeliac Disease
AUTHORS:
Fathima Assainar, Joshua George Thomas, Zoya Saleem, Shafa Thekkekara, Fathima Mammoo, Navadir Nidal Kallan
KEYWORDS:
Exosomes, Cancer, Coeliac Disease, Therapeutic Potential, Cell Communication, Anti-inflammation
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.12 No.3,
March
8,
2024
ABSTRACT: The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provides an overview of exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic effect is that the phospholipid-binding protein ANXA1 improves its anti-inflammatory properties. The review also analyzes the intricate processes of exosome production and composition ability to transport biomolecules such as proteins, microRNAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of targeted drug administration due to their innate specificity. Through genetic engineering and chemical modifications, exosomes can be tailored for specific purposes, demonstrating their versatility in targeted therapy. With ongoing research uncovering their therapeutic potential, exosomes present a promising frontier in novel medical treatments across various health conditions.