TITLE:
Antibiotic Resistance Profile of Salmonella Strains Isolated at the National Clinical Biology and Public Health Laboratory in Bangui, Central African Republic
AUTHORS:
Marceline Djeintote, Ernest Lango-Yaya, Zéphirin-Dalengat Vogbia, Clotaire Donatien Rafaï, Augustin Balekouzou, Henri Saint-Claver Djemer, Wilfried Sylvain Nambei, Boniface Koffi, Gérard Gresenguet
KEYWORDS:
Salmonella, Resistance, Antibiotics, Central African Republic
JOURNAL NAME:
Health,
Vol.16 No.2,
February
29,
2024
ABSTRACT: In Africa, each year, there are estimated to be more than 91 million cases of salmonellosis and 137,000 cases of death. The problem of antibiotic resistance
in Salmonella strains is a threat to
public health. The objective of this study is to evaluate the antibiotic
resistance profile of Salmonella strains isolated in biological products analyzed at the National Laboratory of
Clinical Biology and Public Health (NLCBPH) in Bangui. This is, therefore, a cross-sectional study with a descriptive aim,
running from January to December 2022. It focused
on the strains of Salmonella isolated
and identified in stools, urines, and blood samples. For each strain of Salmonella isolated, an antibiogram was carried out following the recommendations of the French Society of
Microbiology (CASFM, 2022). A total of 93 strains of Salmonella have been recorded. The age group 0 - 9 years
was 29% and that of >50 years was 11%. The median age of patients was 30
years with a minimum of 1 and a maximum of 78
years. The female gender was more represented at 52.69% than the male gender at 47.31%, i.e. a sex ratio of
0.89 (M/F). Salmonella strains were
much more isolated in stools at 62% followed
by urines at 29% and blood at 6%. Salmonella arizonae strains were more represented with 52%. Salmonella strains have a resistance rate to Tetracycline of 62.37%
followed by Penicillins of 50%. The rate of multi-antibiotic resistance of the Salmonella strains isolated represented
48.38%. Salmonella spp. strains were multi-resistant
at 58.69% followed by Salmonella arizonae strains at 47.91%.
There is a significant association between the
different families of antibiotics and Salmonella strains (p Salmonella strains. No strain-producing Broad Spectrum Beta-lactamase has
been isolated. Salmonella strains represent a zoonotic health danger, constitute a public health problem
and remain a current subject. This germ is resistant to the antibiotics used.
It is, therefore, essential to emphasize monitoring the resistance of these germs in the Central African Republic (CAR) to
improve the health of the population.