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Higa, K., Higuchi, J., Kimoto, R., Miyashita, H., Shimazaki, J., Tsubota, K. and Shimmura, S. (2020) Human Corneal Limbal Organoids Maintaining Limbal Stem Cell Niche Function. Stem Cell Research, 49, Article ID: 102012.
https://doi.org/10.1016/j.scr.2020.102012

has been cited by the following article:

• TITLE: The Limbal Niche and Its Role in Maintaining Corneal Regeneration

  AUTHORS: Jaysukh P. Singh

  KEYWORDS: Cornea, Limbus, Molecular Biology, Stem Cells, Lineage Tracing, Live Imaging

  JOURNAL NAME: Open Journal of Ophthalmology, Vol.14 No.1, February 29, 2024

  ABSTRACT: In recent years, stem cells have been a focal point in research designed to evaluate the efficacy of ophthalmologic therapies, specifically those for corneal conditions. The corneal epithelium is one of the few regions of the body that maintains itself using a residual stem cell population within the adjacent limbus. Stem cell movement has additionally captivated the minds of researchers due to its potential application in different body regions. The cornea is a viable model for varying methods to track stem cell migratory patterns, such as lineage tracing and live imaging from the limbus. These developments have the potential to pave the way for future therapies designed to ensure the continuous regeneration of the corneal epithelium following injury via the limbal stem cell niche. This literature review aims to analyze the various methods of imaging used to understand the limbal stem cell niche and possible future directions that might be useful to consider for the better treatment and prevention of disorders of the cornea and corneal epithelium.