TITLE:
Effect of Aqueous Extract of Boscia senegalensis on Hyperglycemia, Hyperlipidemia and Oxidative Stress Induced in Rats
AUTHORS:
Faustin Dongmo, Elie Baudelaire Djantou, Alcherif Hamid Mahamat, Selestin Sokeng Dongmo, Nicolas Njintang Yanou
KEYWORDS:
Boscia Senegalensis, Hypoglycemic, Hypolipidemic, Hyperlipidemic Diet, An-tioxidant
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.14 No.1,
February
29,
2024
ABSTRACT: Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensis seed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.