TITLE:
Pregnancy and Obstetrical Outcomes Following Treatment for Cervical Intra-Epithelial Neoplasia (CIN) in Two Hospitals of a Low-Resource Country
AUTHORS:
Bruno Kenfack, Clovis-Achille Tanekeu, Atem Bethel Ajong, Zabdielle Blonde Goufack Kenfack, Patrick Petignat, Pierre Marie Tebeu
KEYWORDS:
Cervical Intraepithelial Neoplasia, Cervical Treatment, Pregnancy Outcome
JOURNAL NAME:
Advances in Reproductive Sciences,
Vol.12 No.1,
February
27,
2024
ABSTRACT: Objective: In
Cameroon, more than 80% of women suffering from cervical intraepithelial
neoplasia (CIN) are within the reproductive age. This study intended to analyze
the pregnancy outcomes following cervical treatment in Cameroon. Methods: This
was a cohort study with two years retrospective data collection involving 82
women who underwent cervical treatment for CIN in two Cameroonian hospitals
from January 2015 to December 2017. Data were collected from CIN treatment to
end of pregnancy where applicable. Data analysis was done using Epi Info software
version 3.5.4. Results: We
collected data from 82 patients aged 27 to 48 years, with a mean age of 36.5
(SD: 5.3) years. During the study period, 33 out of 82 participants became
pregnant 40.2 [29.56 - 51.66]%. The factor associated with pregnancy occurrence
after treatment was age less than 35 years (Odds ratio = 4.37 [1.7 - 11.2]. From the 33 pregnancies recorded, 17 (51.5%) ended in a delivery,
amongst which 15 (88.2%) were vaginal. Conclusion: Pregnancy frequency over two years following cervical treatment for CIN
was relatively good, and younger women (age 35
years) were significantly more like to have conceived compared to their older
counterparts. Post-treatment delivery outcomes seem to be similar to those in
the general population.