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Mathur, R.K., Awasthi, A., Wadhone, P., Ramanamurthy, B. and Saha, B. (2004) Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nature Medicine, 10, 540-544. doi:10.1038/nm1045

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• TITLE: Modulation of human B lymphocyte differentiation by therapeutic immunoglobulins: from protein to mRNA levels

  AUTHORS: Nathalie Dussault, Nellie Dumont, Sonia Néron

  KEYWORDS: Human B Lymphocytes; CD40-CD154; IVIg; Differentiation; Immunomodulation

  JOURNAL NAME: Open Journal of Immunology, Vol.1 No.3, December 31, 2011

  ABSTRACT: Several groups are investigating the mechanisms of action of therapeutic immunoglobulins (IVIg) in order to improve their use. In vitro models such as CD40-CD154 interaction are necessary to study the physiological response of human B lymphocytes to IVIg. Human B lymphocytes treated with IVIg triggers a rapid phospho-rylation (