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Stewart, R., Wei, W.B., Challa, A., Armitage, R.J., Arrand J.R., Rowe, M., Young, L.S., Eliopoulos, A. and Gordon, J. (2007) CD154 tone sets the signaling pathways and transcriptome generated in model CD40-Pluricompetent L3055 Burkitt’s lymphoma cells. Journal of Immunology, 179, 2705-2712.

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• TITLE: Modulation of human B lymphocyte differentiation by therapeutic immunoglobulins: from protein to mRNA levels

  AUTHORS: Nathalie Dussault, Nellie Dumont, Sonia Néron

  KEYWORDS: Human B Lymphocytes; CD40-CD154; IVIg; Differentiation; Immunomodulation

  JOURNAL NAME: Open Journal of Immunology, Vol.1 No.3, December 31, 2011

  ABSTRACT: Several groups are investigating the mechanisms of action of therapeutic immunoglobulins (IVIg) in order to improve their use. In vitro models such as CD40-CD154 interaction are necessary to study the physiological response of human B lymphocytes to IVIg. Human B lymphocytes treated with IVIg triggers a rapid phospho-rylation (