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Néron, S., Nadeau, P.J., Darveau, A. and Leblanc, J.F. (2011) Tuning of CD40-CD154 Interactions in Human B-Lymphocyte Activation: A Broad Array of In Vitro Models for a Complex in vivo Situation. Archivum Immunologiae et Therapiae Experimentalis, 59, 25-40.

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• TITLE: Modulation of human B lymphocyte differentiation by therapeutic immunoglobulins: from protein to mRNA levels

  AUTHORS: Nathalie Dussault, Nellie Dumont, Sonia Néron

  KEYWORDS: Human B Lymphocytes; CD40-CD154; IVIg; Differentiation; Immunomodulation

  JOURNAL NAME: Open Journal of Immunology, Vol.1 No.3, December 31, 2011

  ABSTRACT: Several groups are investigating the mechanisms of action of therapeutic immunoglobulins (IVIg) in order to improve their use. In vitro models such as CD40-CD154 interaction are necessary to study the physiological response of human B lymphocytes to IVIg. Human B lymphocytes treated with IVIg triggers a rapid phospho-rylation (