TITLE:
Effect of Trimetazidine on Functional Capacity in Patient with Ischaemic Cardiomyopathy (TOFCAPI)
AUTHORS:
Mohsin Ahmed, Golam Morshed, Mahmood Hasan Khan, Md. Arifur Rahman, Muhammed Aminur Razzaque, Shariful Islam, Sayeedur Rahman Khan, Chowdhury Md. Kudrat-E-Khuda, Salahuddin Anis Shiblee, Md. Habibur Rahman
KEYWORDS:
Bangladesh, Heart Failure, Exercise Capacity, Trimetazidine, Ischaemic Cardiomyopathy
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.15 No.2,
February
26,
2024
ABSTRACT: Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.