TITLE:
Profile of Autoimmune Polyendocrinopathies at the Medical Clinic II of the Abass Ndao Hospital: About 40 Cases
AUTHORS:
Michel Assane Ndour, Djiby Sow, Mouhamed Dieng, Ibrahima Mané Diallo, Boundia Djiba, Mélaine Honorine Olympio, Julie Borges Preira, Muriel Diembou, Fatou Kiné Gadji, Fama Ndiaye, El Hadj Mamadou Moussa Thioye, Charles Halim, Demba Diédhiou, Anna Sarr, Maïmouna Ndour Mbaye
KEYWORDS:
APS, Biermer, Graves’ Disease, Hashimoto’s, Addison’s, Vitiligo, Senegal
JOURNAL NAME:
Open Journal of Internal Medicine,
Vol.14 No.1,
February
26,
2024
ABSTRACT: Introduction: Autoimmune polyendocrinopathies (AP) represent a group of rare concomitant pathologies, making them underdiagnosed. The objective was to study their profile at the Medical Clinic II of the Abass Ndao Hospital. Patients and Methods: This was an observational, descriptive and analytical study, lasting 24 months, from January 1, 2020 to December 31, 2022. We assessed the epidemiological, clinical and paraclinical characteristics of the patients and classified the APs found. Results: We included 40 patients divided into type III (38 cases) and IV (2 cases). A female predominance was noted with a sex ratio of 0.21. The mean age was 38.6 years. A family history of component diseases of autoimmune polyendocrine syndrome (APS) was found in 62.5%. Goiter (80%) was the main clinical sign present. All 38 patients with ISAP-3 had autoimmune thyroiditis, including 29 cases of Graves’ disease (72.5%) and 9 cases of Hashimoto’s thyroiditis (22.5%). They were associated with either type 1 diabetes (57.9%), Biermer’s disease (21.1%), vitiligo + alopecia (18.4%), lupus (2.6%). The 2 patients with AP-4 had Biermer’s disease associated with either Addison’s disease or type 1 diabetes. Management depended on the pathologies present and their possible complications. The immunological phenomena were also controlled. Conclusion: This series is globally similar to the literature. The polymorphous character of the clinical pictures requires a better collaboration between specialists leading to a clinical and holistic synthesis.