TITLE:
Effect of flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients
AUTHORS:
Jiaxin Lin, Hui Yang, Shaofen Chen, Jiao Xu
KEYWORDS:
SIRS, Systemic Inflammatory Response Syndrome, IL-6, Interleukin-6, CRP, C-Reactive Protein
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.15 No.2,
February
22,
2024
ABSTRACT: Objective:To determine the effect of
flurbiprofen combined with prednisolone on interleukin-6 in elderly surgery patients. Methods: In this double-blind randomized controlled study, patients aged 65 to 80
who were undergoing spinal fusion surgery for disc herniation were administered
flurbiprofen 100 mg (P group, flurbiprofen group),
prednisolone 0.6 mg/kg (D group, prednisolone group), prednisolone 0.6 mg/kg plus flurbiprofen 100 mg
(P + D group, flurbiprofen + prednisolone group) or normal
saline (S group, saline group) 15 minutes before the
induction of anesthesia. Plasma samples were collected before surgery (T0) and on day 1 (T1), day 2
(T2) and day 3 (T3) following surgery. At the same time, systemic
inflammatory response syndrome (SIRS) was assessed by SIRS criteria. The levels
of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)
and C-reactive protein (CRP) for collected samples were measured. Results: Other
groups had significantly lower levels of IL-6, CRP and occurrence of SIRS than
S group (p + D group were significantly lower on T1 (p p 0.05). The levels of CRP within three days were
significantly different but did not show
peak levels (p > 0.05). Conclusion: Compared to prednisolone or flurbiprofen, combining flurbiprofen with
prednisolone in elderly surgery patients led to an increased suppression of
IL-6.