TITLE:
Alternative Phenotypic Profile for B-Cell Abnormality in a Case at Zinder National Hospital
AUTHORS:
Brah Moustapha Maman, Amadou Djibrilla-Almoustapha, Moustapha Elhadji-Chefou, Abdoul-Aziz Garba, Badé Malam-Abdou
KEYWORDS:
Hyperlymphocytosis, CLL, Immunophenotyping, MINICHOP
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.14 No.1,
February
1,
2024
ABSTRACT: Introduction: Since
it is impossible to establish a diagnosis in the presence of hyperlymphocytosis
not secondary to lymphocytic hyperactivation, we considered a B-lymphoid
hematopathy with a non-specific phenotypic profile. We report one case of this. Observation: This is a forty-eight (48) year old patient with
hyperlymphocytosis at 139,000 elements per cubic millimeter, heterogeneous
splenomegaly at 25.6 cm in diameter on abdominal ultrasound without detectable
deep or peripheral lymphadenopathy. Peripheral blood cytology shows lymphocyte
cell proliferation suggestive of the circulating phase of chronic
lymphoproliferative B syndrome. The expression profile of cell membrane markers
did not allow for the definition of a specific phenotypic profile. Faced with this immunophenotyping result, we
considered a B-lymphoid hemopathy with a non-specific phenotypic profile. After
three courses, the MINICHOP treatment was used to achieve partial remission
with wasting of more than 80% of the evaluable masses. Conclusion: Despite the contribution of immunophenotyping in the diagnosis of
lymphoproliferative syndromes, it is possible to consider the diagnosis of a B-lymphoid
hemopathy with a phenotypic non-specific profile of CD45+, monotypic kappa, CD19+, FMC7+, CD22+, CD5−, CD79b−, CD23−, CD43−, CD38−, CD200−.