TITLE:
A Clinical Study to Assess the Effectiveness of Oral Combination Kit Therapy in Syndromic Management of Abnormal Vaginal Discharge (FEMINE Study) in Kinshasa, Democratic Republic of Congo
AUTHORS:
Feruzi Michel Mangala, Muela Andy Mbangama, Di-Mosi-Nkoy Roger Wumba, Ambis Joëlle Lumaya, Nkongolo Freddy Muamba, Tshitadi Jean Mukendi, Ndombasi Neilda Lemba, Otem Christian Ndesanzim, Nkashama Bienvenu Kazadi, Banza Jesual Lotoy, Umba Adrien Tandu, Mushengezi Dieudonné Sengeyi, Mwimba Roger Mbungu
KEYWORDS:
Oral Combination Kit Therapy, Syndromic Management, Abnormal Vaginal Discharge
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.14 No.1,
January
31,
2024
ABSTRACT: Background: Vaginal discharge is one of most common and nagging problems that women
face. About 20% - 25% of women who visit
gynecology department complain of vaginal discharge and leucorrhoea. An orally
administered combination kit, containing 2 g
secnidazole, 1 g azithromycin
and 150 mg
fluconazole (Azimyn FS Kit), has been
successfully evaluated in clinical trials and used in several countries for
management syndromic vaginal discharge due to infections. Methods: This is a longitudinal
study which aimed to verify the clinical efficacy of the combined oral kit
containing secnidazole, azithromycin and fluconazole (Azimyn FS Kit®) in the
syndromic treatment of abnormal vaginal discharge in patients received in
outpatient consultations in Kinshasa/DR Congo from March to September 2023. Results: Majority of patients had
whitish vaginal discharge (51.6%) of average abundance (56.2%), accompanied by
pruritus in 72.1% of cases, and dyspareunia in 23.5% of cases and
hypogastralgia in 40.2% of cases. One week after treatment with the Azimyn FS® combined
kit, at the greatest majority of patients (97.3%), abnormal vaginal discharge
had decreased by more than 50% (84.1%). Two weeks after treatment with the
Azimyn FS® combined kit, almost all patients (97.3%) no longer had abnormal vaginal
discharge which had completely disappeared. Conclusion: A single dose of secnidazole, azithromycin and fluconazole in the form of an oral combi-kit
(Azimyn FS Kit) has shown excellent therapeutic effectiveness in the syndromic
treatment of abnormal vaginal discharge wherein patients were treated without diagnostic confirmation.