TITLE:
COVID-19 Vaccination Status and Severe Outcomes among Patients Hospitalized for COVID-19 in West Africa, Togo, 2021
AUTHORS:
Awèréou Kotosso, Yao Rodion Konu, Lidaw Déassoua Bawe, Sarakawabalo Assenouwe, Yawovi Mawufemo Tsevi, Koffi Atsu Aziagbe, Akouda Akessiwe Patassi, Bawoubadi Abaltou, Gnimdou Tchamdja, Lampouguini Nebona, Komi Séraphin Adjoh, Didier Ekouevi, Majesté Ihou Wateba
KEYWORDS:
COVID-19, Vaccination, Prognosis, Mortality, Sub-Saharan Africa
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.14 No.1,
January
31,
2024
ABSTRACT: Objectives: More than a year after its introduction, COVID-19 vaccination coverage was low in the Togolese population and little data were available on its benefits for hospitalized patients. This study aimed to describe the impact of COVID-19 vaccination on the prognosis of hospitalized patients. Methods: This was a retrospective cohort study of patients admitted to the Centre Hospitalier Régional Lomé Commune (Togo) between June 1, 2021 and May 31, 2022. Primary outcomes (admission to the intensive care unit and death) were presented with frequency and proportion. Mortality rates were presented by sociodemographic and clinical characteristics and compared by appropriate statistical tests. Factors associated with inpatient death were described by performing a Cox proportional hazard regression. Results: A total of 604 patients were hospitalized (50.0% women). The mean age was 54.03 ±17.1 years. Only 55 patients were fully vaccinated (9.1%). ICU admission was significantly more frequent in unvaccinated patients than in vaccinated ones (63.0% vs. 38.2%; p Conclusion: COVID-19 vaccination had a significant benefit for patients with COVID-19 infection in terms of reducing the risk of death. Based on real-world data from sub-Saharan Africa, this information can help optimize the benefit of COVID-19 vaccination by raising community awareness and increasing vaccine coverage while reducing hesitancy.