Article citationsMore>>

Nagtegaal, I.D., Odze, R.D., Klimstra, D., Paradis, V., Rugge, M., Schirmacher, P., Washington, K.M., Carneiro, F. and Cree, I.A. (2020) The 2019 WHO Classification of Tumours of the Digestive System. Histopathology, 76, 182-188.
https://doi.org/10.1111/his.13975

has been cited by the following article:

• TITLE: Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm (MiNEN) of the Colon: A Case Report

  AUTHORS: Amira Mohammad, Azah Syahrina Alias

  KEYWORDS: Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms (MiNENs), Contrast-Enhanced Computed Tomography (CECT), Carcinoembryonic Antigen (CEA)

  JOURNAL NAME: Open Journal of Pathology, Vol.14 No.1, January 29, 2024

  ABSTRACT: Here we report a rare case of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs). A 51-year-old lady with no known family history of malignancies developed this rare type of malignancy without any active gastrointestinal symptoms. However, during a routine health check, physicians noticed a raised Carcinoembryonic Antigen (CEA) level and the patient subsequently was referred to the surgical department for further management. A colonoscopy and CECT abdomen were done and she was electively admitted for a left hemicolectomy operation for a splenic flexure tumour. The histopathological report revealed the tumour is a case of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) [moderately differentiated adenocarcinoma and neuroendocrine tumour grade 3]. TNM (8th edition, 2016): pT3, pN2 (20/21), pMX. Both resection margins were clear from malignant cells. Colorectal MiNENs, constitute a rare group of gastrointestinal tumours composed of both neuroendocrine and non-neuroendocrine components. Given their non-diagnostic macroscopic features, specific histological features and lack of disease awareness which are responsible for the underestimated incidence and conflicting data. In this case, a multidisciplinary team approach is important in managing patients with this malignancy to achieve the best outcome.