TITLE:
A Potential Role for GLUT4 in Predicting Sepsis in Critically Ill Children
AUTHORS:
Yanna Zhou, Guangming Liu, Xiaohui Wu, Aidi Kuang, Cuiping Zhu#, Qiuyan Peng#
KEYWORDS:
Children, Critical Illness, Glucose Transporter Type 4, Hyperglycemia, Insulin Resistance
JOURNAL NAME:
Open Journal of Internal Medicine,
Vol.14 No.1,
December
29,
2023
ABSTRACT: Background: This study investigated serum Glucose transporter (GLUT) 4 levels and examined the relationship between serum GLUT4 levels and sepsis in critically ill children. Methods: This was a retrospective study of 77 critically ill children and 33 non-diabetic healthy children (controls) who were admitted between 07/2015 and 05/2016. Patient data, clinical information, and blood samples were collected on admission, alongside a large number of laboratory parameters that were routinely assessed. Critically ill patients were divided into sepsis and non-sepsis/systemic inflammatory response syndrome (SIRS). Serum GLUT4 was measured using western blotting and enzyme-linked immunosorbent assays. Insulin resistance indexes, clinical data, laboratory parameters, and inflammatory cytokines were assessed. Results: GLUT4 serum levels were higher in critically ill children than in healthy children (90.5 vs. 30.3 μg/L, P 0.05). Compared to healthy children, hyperglycemic patients (n = 48) had elevated GLUT4 serum levels (30.3 vs. 103.7 g/L, P Conclusions: GLUT4 serum levels might be significantly increased in critically ill children compared with healthy children, particularly those in septic shock. Serum GLUT4 could predict disease severity.