TITLE:
Macrophage Activation Syndrome as the Primary Presentation of Pediatric Systemic Lupus Erythematosus: A Case Report and Review of the Literature
AUTHORS:
Hanane Hajaj, Hanae Bahari, Aziza El Ouali, Ayyad Ghanam, Maria Rkain, Abdeladim Babakhouya
KEYWORDS:
Macrophage Activation Syndrome, Systemic Lupus Erythematosus, Child
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.14 No.1,
January
23,
2024
ABSTRACT: Macrophage activation syndrome (MAS), in its secondary form, often
complicates rheumatic diseases but rarely constitutes a mode of revelation.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown
etiology that primarily affects women in adulthood. MAS is a serious condition
that may be the first presentation of SLE. Here, we report the case of a
4-year-old female with MAS as the primary manifestation of Systemic Lupus
Erythematosus (SLE). In this case, we outline the characteristics of a complex
case of SLE that was initially accompanied with MAS, and also review the
literature to discuss the clinical, biological, and therapeutic aspects of this
condition.