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Zhu, X., Liang, Y., Mao, Y., Jia, Y., Liu, Y. and Mu, G. (2008) Analyses and calculations of noise in optical coherence tomography systems. Frontiers of Optoelectronics in China, 1, 247-257. doi:10.1007/s12200-008-0034-0

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• TITLE: Imaging of arterial plaque by quadrature swept-source optical coherence tomography with signal to noise ratio enhancements

  AUTHORS: Youxin Mao, Costel Flueraru, Shoude Chang

  KEYWORDS: Optical Coherence Tomography; Arterial Plaque; Medical and Biological Imaging; Semiconductor Optical Amplifier

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.12, December 9, 2011

  ABSTRACT: Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using a signal to noise ratio enhanced swept-source optical coherence tomography system with a quadrature interferometer (QSS-OCT). A semiconductor optical amplifier is used in the sample arm to amplify the weak signal scattered from arterial plague. Signal to noise ratio improvement are demonstrated in our QSS-OCT system. This finding results into an increase of the penetration depth possible in OCT images, from 1 mm to 2 mm. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with our QSS-OCT system.