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Jang, I.K., Bouma, B.E., Kang, D.H., Park, S.J., Park, S.W., Seung, K.B., Choi, K.B., Shishkov, M., K. Schlendorf, Pomerantsev, E., Houser, S.L., Aretz, H.T. and Tearney, G.J. (2002) Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound. Journal of the American College of Cardiology, 39, 604-609. doi:10.1016/S0735-1097(01)01799-5

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• TITLE: Imaging of arterial plaque by quadrature swept-source optical coherence tomography with signal to noise ratio enhancements

  AUTHORS: Youxin Mao, Costel Flueraru, Shoude Chang

  KEYWORDS: Optical Coherence Tomography; Arterial Plaque; Medical and Biological Imaging; Semiconductor Optical Amplifier

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.12, December 9, 2011

  ABSTRACT: Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using a signal to noise ratio enhanced swept-source optical coherence tomography system with a quadrature interferometer (QSS-OCT). A semiconductor optical amplifier is used in the sample arm to amplify the weak signal scattered from arterial plague. Signal to noise ratio improvement are demonstrated in our QSS-OCT system. This finding results into an increase of the penetration depth possible in OCT images, from 1 mm to 2 mm. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with our QSS-OCT system.