TITLE:
Association between the Different Phenotypes of Polycystic Ovary Syndrome and the Outcome in in Vitro Fertilization at Human Reproductive Center Paul et Chantal Biya-Yaoundé
AUTHORS:
Ngono Akam Vanina, Ngah Minala, Belinga Etienne, Belinga Etienne, Mpono Pascale, Nyada Serges, Onana Y. Kasia, Cho Joselyne, Kasia Florence, Adjessa Abega, Kasia Jean Marie
KEYWORDS:
Phenotype, Polycystic Ovarian Syndrome, IVF/ICSI, Prognosis, CHRACERH
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.14 No.1,
January
12,
2024
ABSTRACT: Background: In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) represents the final
step in the management of Polycystic Ovarian Syndrome (PCOS). Our objective was
to study the association between PCOS phenotypes and IVF/ICSI results in women
admitted to Gynaecological Endoscopic Surgery and Human Reproductive Teaching
Hospital (CHRACERH). Material and Method: We carried out a cohort study
with historical-prospective data collection over a period of seven years
(January 2016 to March 2023) at Chracerh. PCOS patients were subdivided into 4 subgroups A, B, C and D. Results: We recruited 128 patients including 64 PCOS patients divided into four
phenotypes and 64 non-PCOS patients constituting the control group. Phenotype D
without hyperandrogenism had used the lowest dose of gonadotropins, i.e. 1939.7 ± 454.3 IU, and had produced
a greater quantity of estradiol on the day ovulation was triggered (6529.8 ± 4324.8
ng/ml). The average number of punctured follicles and mature oocytes were
higher in the phenotype D group. Ovarian hyperstimulation syndrome (OHSS)
occurred mainly in phenotype D (3/35), with an estimated prevalence of 2.3%.
The fertilization rate seemed lower in the hyperandrogenic phenotypes A, B, C
compared to the group without hyperandrogenism
without significant difference (p = 0.461). The biological pregnancy rate and
live birth rate were comparable between the different groups. Conclusion: Phenotype
D used less dose of gonadotropins. Biological pregnancy and live birth rates
were comparable between the different phenotypes.