TITLE:
Aminated (Cyclopropylmethyl)Phosphonates: Synthesis and Anti-Pancreatic Cancer Activity
AUTHORS:
Abed Al Aziz Al Quntar, Ibrahim Abasy, Hasan Dweik, Michel Maffei, Valery M. Dembitsky
KEYWORDS:
Phosphonates, Aminophosphonates, Pancreatic Cancer, Cancer, Cyclopropylphosphonates
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.13 No.4,
December
22,
2023
ABSTRACT: Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of Hunig’s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.