TITLE:
Laboratory Diagnosis of Acute Leukemia in Kenya: The Gaps and Opportunities
AUTHORS:
Teresa Lotodo, Kirtika Patel, Isaac Ndede
KEYWORDS:
Acute Leukemia, Complete Blood Counts, Peripheral Blood Film, Bone Marrow Aspirates, Flow Cytometry, Cytogenetics, Molecular Tests
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.11 No.12,
December
8,
2023
ABSTRACT: Acute leukemia (AL) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. The diagnosis of leukemia and lymphomas, beyond morphology, is limited in low-resource countries including Kenya. Morphological diagnosis includes Cytological and Histological assessment of blood, bone marrow aspirates and tissues on suspected Acute leukemia patients. The World Health Organization (WHO, 2016) international guidelines on Acute leukemia diagnosis recommend that cytogenetic analysis, appropriate molecular genetics, Fluorescent in situ Hybridization (FISH) testing, and flow cytometric immuno-phenotyping should be done in addition to a morphologic assessment of Acute Leukemia. In facilities where resources are relatively available, immunophenotypic and genetic features have resulted not only in providing a more accurate leukemia diagnosis but also in identifying antigens or genes that can then be targeted for therapy. This article will look at the gaps in the diagnosis of Acute leukemia in low-resource settings like Kenya and opportunities available to improve diagnosis.