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Maude, R.J., Plewes, K., Faiz, M.A., Hanson, J., Charunwatthana, P., Lee, S.J., Tarning, J., Yunus, E.B., Hoque, M.G., Hasan, M.U., Hossain, A., Lindegardh, N., Day, N.P., White, N.J. and Dondorp, A.M. (2009) Does Artesunate Prolong the Electrocardiograph QT Interval in Patients with Severe Malaria? The American Journal of Tropical Medicine and Hygiene, 80, 126-132.
https://doi.org/10.4269/ajtmh.2009.08-0326

has been cited by the following article:

• TITLE: Histopathological Evaluation of the Cardiotoxicity of Dihydroartemisinin-Piperaquine on Male Albino Rats

  AUTHORS: Ramson Chinemerem Achilefu, Ugonma Kendra Jumbo, Daniel Chukwudi Oti, Christian Kelechi Agwaraonye, Ozioma Pricilla Okezie, Wendy Chidera Anyanwu

  KEYWORDS: Dihydroartemisinin-Piperaquine, Histopathological Evaluation, Cardiac Muscles, Albino Rats

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.12, December 8, 2023

  ABSTRACT: Problem Statement: Malaria’s global impact necessitates effective treatments, like dihydroartemisinin-piperaquine (DHA/PQP), though safety concerns, notably drug-induced cardiotoxicity (DICT), persist. A knowledge gap exists regarding DHA/PQP’s cardiac effects, warranting a comprehensive investigation. Approach: This study aimed to assess KROSH (DHA/PQP) impact on albino rat heart histology, examining structural changes and potential cardiotoxicity. 40 albino rats were grouped by KROSH dosage and duration, monitored for weight changes, and heart tissues were examined using hematoxylin and eosin (H & E) staining. Statistical analysis compared to control and treated groups. Results: KROSH administration led to varying rat weight effects, yet not statistically significant. Histological analysis revealed dose and duration-dependent cardiac tissue alterations, including distortion, adipose deposits, artery hypertrophy, fibrosis, and necrosis. These contrasts with prior research documenting DHA/PQP’s non-toxic effects. Conclusion/Recommendation: This study highlights potential KROSH (DHA/PQP) cardiotoxicity concerns through histological changes, underscoring the need for further research into underlying mechanisms and human health implications. Given DHA/PQP’s wide use, these findings should inform safety evaluations and administration practices.