TITLE:
Glycyrrhizic Acid-Loaded Poly-ɛ-Caprolactone Nanoparticles Decrease PRRSV Infection in MARC-145 Cells
AUTHORS:
Samantha Jardon, Oscar Escalona, Carlos Gerardo García, David Quintanar, Carlos Ignacio Soto, María Zaida Urbán Morlán, Susana Elisa Mendoza
KEYWORDS:
Cytotoxicity, Glycyrrhizic Acid, Cell Morphology, Polymeric Nanoparticles, PRRS Virus
JOURNAL NAME:
Open Journal of Veterinary Medicine,
Vol.13 No.12,
December
8,
2023
ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating disease with worldwide distribution caused by Betaarterivirus suid (PRRSV). The virion has great genetic and antigenic variability with a marked increase in virulence. Vaccines tested to date have been of little use in controlling the problems caused by PRRSV, so the present study was conceived to evaluate the antiviral effect of polymeric nanoparticles (PNPs) made with glycyrrhizic acid (GA). Recent work has proven that this nanoparticle system is stable. These nanoparticles have good GA carrying capacity, a size