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Gupta, A., Inaba, S., Wong, O.K., Fang, G. and Liu, J. (2003) Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene, 22(48), 7593-7599.

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• TITLE: Patterns of synuclein expression throughout lens development

  AUTHORS: Irina Surgucheva, Belinda MacMahon, Andrei Surguchov

  KEYWORDS: Lens; Crystallins; Synucleins; Promoter; Chaperones; Heat Shock Proteins

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.1 No.1, June 1, 2010

  ABSTRACT: Synucleins belong to a family of small soluble proteins with chaperonic activity implicated in human diseases, but their normal function is not completely understood. Expression of ?, ? and ?-synucleins was analyzed in rat and human lens on different stages of development. No significant expression of ?- and ?-synucleins were found, whereas ?-synuclein was expressed in both species only on early stages of lens development. Examination of ?-synuclein upstream region demonstrated the similarity in its organization with promoter regions of crystallins and heat shock protein’s genes. ?-Synuclein upstream region contains motives identical or similar to regulatory cis-elements in their promoters including binding sites for Pax6 and Sox. These results suggest that ?-synuclein plays a role in distinct temporal events in lens development, presumably acting as a specific chaperone.