TITLE:
Association between Hyperhomocysteinemia and Microangiopathic Complications (Neuropathy and Nephropathy) in Subjects with Type 1 and Type 2 Diabetes
AUTHORS:
Nene Oumou Kesso Barry, Soukeyna Gueye, Moustapha Djité, Pape Matar Kandji, Michel Assane Ndour, El Hadj Malick Ndour, Demba Diedhiou, Fatou Gueye-Tall, Ndeye Mareme Thioune, Najah Fatou Coly, Dominique Doupa, Maïmouna Ndour Mbaye, Philomène Lopez Sall, Papa Madieye Gueye
KEYWORDS:
Homocysteine, Hyperhomocysteinemia, Diabetes Mellitus, Type 1 Diabetes, Type 2 Diabetes, Nephropathy, Neuropathy
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.13 No.4,
November
30,
2023
ABSTRACT: This prospective case-control study aimed to assess the prevalence of hyperhomocysteinemia and explore its potential correlation with microangiopathic complications, specifically nephropathy and neuropathy, in a cohort of both type 1 and type 2 diabetic patients. Conducted at the Marc Sankalé Center of Abass Ndao Hospital in Dakar from June to September 2018, the study enrolled a total of 106 diabetic patients, comprising 93 type 2 diabetics and 13 type 1 diabetics, who were matched with control subjects free from clinically detectable pathologies, based on sex and age ± 2 years. The mean age of type 1 and type 2 diabetic patients was 24.46 ± 8.41 years and 57.28 ± 11.28 years, respectively. Our findings revealed a statistically significant elevation in mean homocysteine levels among patients when compared to controls (12.63 vs. 9.88; p