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Zhu, B.D., Yuan, S.J., Zhao, Q.C., Li, X., Li, Y., Lu, Q.Y. (2005) Antitumor effect of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, combined with cytotoxic agent on murine hepatocellular carcinoma. World Journal of Gastroenterology, 11(9), 1382-1386.

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• TITLE: Dicranostigma leptopodum (maxim) fedde induced apoptosis in SMMC-7721 human hepatoma cells and inhibited tumor growth in mice

  AUTHORS: Wen-Hua Zhang, Ming-Hua Lv, Jun Hai, Qin-Pu Wang, Qin Wang

  KEYWORDS: Dicranostigma Leptopodum (Maxim) Fedde; Anti-Tumor Activity; Apoptosis; Tumor-Growth Inhibition

  JOURNAL NAME: Natural Science, Vol.2 No.5, June 1, 2010

  ABSTRACT: Dicranostigma Leptopodum (Maxim) Fedde (DL- F), which had been previously documented to suppress oxidative hemolysis of erythrocytes and enhance immune functions of murine peri- toneal macrophages, was investigated for its effect on anti-tumor activity. Of alkaloids extracted from DLF, five have been identified with employment of chromatographic analysis. An antiproliferative role of these alkaloids was determined on SMMC-7721 Human Hepatoma Ce- lls in an apoptosis-inducing manner, through MTT assaying, Trypan blue exclusion assaying and cytometric analysis of cell cycle distribution. To further examine their inhibitory effects on tumor progression, murine H22 cells were inoculated into Kunming mice to determine the role of these alkaloids of DLF in inhibiting tumor growth in the tumor-implanted mice. It was found that these alkaloids of DLF enhanced the tumor shrinkage effectively wherein its tumor inhibitory rate and immunohistochemistry stain- ing of the tumor were determined and profiled, respectively.