TITLE:
Contribution to the Study of Antibiotic Sensitivity of Streptococcus pneumoniae Strains in Spinal Cerebral Fluids in Bangui from 2017 to 2022
AUTHORS:
Zéphirin-Dalengat Vogbia, Ernest Lango Yaya, Marie Colette-Nganda Banguet, Jean de Dieu Longo, Clotaire -Rafaï, Maurel Anicet Adonis Ouoko Fa-Tigbia, Christian Diamant Mossoro, Gérard Gresenguet
KEYWORDS:
Streptococcus pneumoniae, Sensitivity, Antibiotics, Central African Republic
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.16 No.7,
July
30,
2023
ABSTRACT: A prospective and analytical study was
carried out from January 2017 to Decem-ber 2022, at the National Laboratory of
Clinical Biology and Public Health (LNBCSP) in Bangui. 352 samples of
cerebrospinal fluid (CSF) were confirmed out of 2065, coming from the four
hospitals in Bangui. This study aimed to evalu-ate the evolution of antibiotic
sensitivity to strains of Streptococcus pneumoniae. CSF had been collected from
patients who presented with meningeal syndromes. Based on the leukocyte count
(White blood cells ≥ 5 mm3), an aliquot was trans-ferred to trans-isolate medium and
sent to the LNBCSP for confirmatory testing, culture and determination of antibiotic
sensitivity. The antibiotic sensitivity of Streptococcus pneumoniae strains was
tested according to the methods recom-mended by the Antibiogram Committee of
the French Society of Microbiology. The data collected was entered into Excel
2010 to be analyzed with Epi Info 7.2. Ficher’s exact test, chi2 at the 5%
threshold (p