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Bronsema, K.J., Bischoff, R. and van de Merbel, N.C. (2013) High-Sensitivity LC-MS/MS Quantification of Peptides and Proteins in Complex Biological Samples: The Impact of Enzymatic Digestion and Internal Standard Selection on Method Performance. Analytical Chemistry, 85, 9528-9535.
https://doi.org/10.1021/ac4015116

has been cited by the following article:

• TITLE: Exploration of Related Issues on PK/PD Studies and Bioanalytical Characteristics of Peptides

  AUTHORS: Chiyu He, Yuxi Hu

  KEYWORDS: Peptides, Drugs, PK/PD, Bioanalytical Characteristics

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.11, November 8, 2023

  ABSTRACT: Peptides play multiple functions in cellular processes and are considered an attractive paradigm for the development of novel drugs and therapeutic approaches. However, the complexity of their pharmacokinetics/pharmacodynamics and physicochemical properties presents challenges in their development. Currently, there is no single analytical method that fully meets the requirements for studying peptide drug pharmacokinetics. Interdisciplinary teams and multiple technical platforms are required to address these challenges. This article explores the pharmacokinetics, bioanalytical methods, challenges, and strategies in the development of peptide drugs. As our understanding of peptide drug pharmacokinetics and bioanalytical characteristics deepens, it will facilitate their development and provide scientific evidence for rational clinical use.