TITLE:
The Clinical Outcomes of Mosaic Embryo Transfer in Preimplantation Genetic Testing Cycles
AUTHORS:
Shujing He, Linan Xu, Huiling Pan, Kuan Cheng, Zhiqiang Zhang, Cong Fang, Zi Ren
KEYWORDS:
Mosaic Embryo, PGT, Pregnancy Outcomes, Perinatal Follow-Up
JOURNAL NAME:
Advances in Sexual Medicine,
Vol.13 No.2,
November
8,
2023
ABSTRACT: Purpose: We aimed to analyze the pregnancy outcomes and
perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT)
cycles. Method: We retrospectively selected 27 mosaic embryo transfer
cycles as the study group and 97 euploid embryo transfer cycles as the control
group after propensity score matching, which were performed in the reproductive
medicine center of the Sixth Affiliated Hospital, Sun Yat-sen University, from
March 2019 to September 2023. The biopsy cells from blastocyst were undertaken
next generation sequencing (NGS). Results: No significant difference in
pregnancy outcomes compared between the two groups. According to the size of
aneuploid, fragment the level of mosaicism or blastocyst morphological
gradings, there were no significant difference in mosaic embryo transfers. Conclusion: Mosaic embryo detected in the PGT cycle can lead to clinical pregnancy and live
birth of healthy offspring, which can be considerate suitable for transfer.