TITLE:
Vilsmeier Haack Adducts as Effective Reagents for Regioselective Nitration of Aromatic Compounds under Conventional and Non-Conventional Conditions
AUTHORS:
Kamatala Chinna Rajanna, Mukka Satish Kumar, Purugula Venkanna, Soma Ramgopal, Marri Venkateswarlu
KEYWORDS:
Nitration, KNO3 or NaNO2, Vilsmeier-Haack Reagent, Microwave Irradiation (MWI), Grinding, Sonication
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.1 No.4,
December
27,
2011
ABSTRACT: Nitration of aromatic Compounds is triggered by Vilsmeier-Haack reagent (DMF/POCl3) or (DMF/SOCl2) in the presence of KNO3 or NaNO2 under conventional and non-conventional conditions. The reactions af- forded corresponding Nitro derivatives in very good yield with high regioselectivity. The results obtained in non-conventional methods (Micro wave irradiation, Grinding, Sonication) are comparable with those ob- tained under conventional conditions, but the reaction times of former conditions are substantially shorter than that of the latter.