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M. Malesic, A. Krbavcic, A. Golobic, L. Golic and B. Stanovenik, “The Synthesis and Transformation of Ethyl 2-(2-Acetyl-2-benzoyl-1-ethenyl)amino-3-dimethylaminopropenoate. A New Synthesis of 2,3,4-Trisubstituted Pyrroles,” Journal of Heterocyclic Chemistry, Vol. 34, No. 6, 1997, pp. 1757-1762. doi:10.1002/jhet.5570340619

has been cited by the following article:

• TITLE: Dimethylformamide Dimethyl Acetal (DMFDMA) in Heterocyclic Synthesis: Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and Their Fused Derivatives

  AUTHORS: Fathi A. Abu-Shanab, Sayed A. S. Mousa, E. A. Eshak, Ahmed Z. Sayed, Ahmed Al-Harrasi

  KEYWORDS: DMFDMA, Malononitrile Dimer, Pyridazine-3, 5-carbonitrile, Pyridine-4-alkoxide

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.1 No.4, December 27, 2011

  ABSTRACT: Reaction of N,N’-dimethylformamide dimethyl acetal (DMFDMA) with malononitrile dimer 8 (1:1) mole afforded 9 while, this reaction when carried out in (2:1) mole to give amidine 11 which can be used for the preparation of pyrimidine 13, amidine 14 and pyridine 19 when reacted with 4-nitroaniline, 4-methylaniline and alkoxide respectively. Malononitrile dimer reacted with diazonium chloride to give pyridazine 21, which can be reacted with DMFDMA, AcOH/HCl and cyanoacetamide to give pyridazine 22, 23 and pyrido[4,3-c] pyridazine 24 respectively. The latter reacted with DMFDMA to afford tricyclic compound 25.