TITLE:
The Mechanism and Research Progress of Ferroptosis in Esophageal Squamous Cell Carcinoma
AUTHORS:
Jinmeng Gong, Xiaoping Tan
KEYWORDS:
ESCC, Ferroptosis, System Xc?, GPX4, PUFA, MUFA, Fe2+, ROS, Lipid Peroxidation
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.11 No.10,
October
27,
2023
ABSTRACT: Esophageal squamous cell carcinoma (ESCC), as the main histological type of esophageal cancer (EC), has the characteristics of high malignant degree, high mortality and tendency to lymph node metastasis. Despite the combination of surgery and chemoradiotherapy, ECSS has a poor prognosis. Ferroptosis is a newly discovered iron-dependent programmed cell death pattern characterized by the accumulation of lipid peroxidation and characteristic morphological changes of mitochondria. It regulates the growth and invasion of cancer cells in various tumors such as gastric cancer and pancreatic cancer. In this article, we mainly introduce the ferroptosis regulatory mechanism in ESCC, hoping to provide a new direction and ideas for the treatment of ECSS.