TITLE:
Epithelial Ovarian Cancer Patients and Clinicopathological Features and Survival: A Comparison of Outcomes of Two Age Cohorts in Bangladesh
AUTHORS:
Farhana Haque, Shahana Pervin, Annekathryn Goodman
KEYWORDS:
Epithelial Ovarian Cancer, Age, Survival, Bangladesh
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.14 No.10,
October
26,
2023
ABSTRACT: Objective: This study compared the clinicopathologic
characteristics and overall survival of epithelial ovarian carcinoma in women younger versus older
than 45 years in Bangladesh. Methods: A retrospective analysis identified 129
epithelial ovarian carcinoma patients who were admitted to the National
Institute of Cancer Research and Hospital, in Dhaka, Bangladesh from 2016
through 2017 for surgery. These patients were grouped into two categories: the younger
group (≤45 years) and the older group (>45 years). Clinicopathological features of epithelial
ovarian carcinoma were analyzed in each age group. Cox proportional
hazards model identified factors affecting survival and Kaplan-Meier survival
curves with log rank test compared outcomes for each age group. Results:
The median age of the 129 women was 46 years (IQR: 38, 56) and median time of
follow-up was 9 months (inter-quartile range: 4, 26.5). We found a significant
difference in the CA-125 level (p there was a higher probability of death among the older
cohort. The 5-year overall survival rates for the
younger age versus older group were 34.0%, and 11.7% respectively. Independent
prognostic factors by univariate analysis for the overall survival were age,
FIGO stage, preoperative CA-125 and CEA level. However, when controlling for
stage, survival was similar between age cohorts. Conclusions: Our data
suggests that women in Bangladesh with epithelial ovarian cancer who are under the
age of 45 years have a different clinical profile and better overall survival
than women in the older age cohort.