TITLE:
Antinociceptive Effect of Methanol Extract of Diospyros malabarica (Desr.) Kostel Leaves in Mice
AUTHORS:
Md. Azim Uddin, Ambia Khatun, Md. Abdul Mannan
KEYWORDS:
Diospyros malabarica, Extract, Antinociceptive, Pain
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.14 No.9,
September
21,
2023
ABSTRACT: Background: Diospyros malabarica (Desr.) Kostel,
a small to medium-sized tree in the Ebenaceae family, is known as “Deshi Gab”
in Bangladesh. Fever, diabetes, snake bite, diarrhea, biliousness, and ulcer
ailments are all treated with the herb. This study’s goal was to examine in
mouse models the antinociceptive properties of methanol extract of Diospyros malabarica leaves (MEDM). Methods: For
the purpose of determining the antinociceptive activity in mice, five distinct
pain models including hot plate, tail immersion, acetic acid-induced writhing,
formalin and glutamate-induced nociception tests were used. The conventional
medications were morphine sulphate (5 mg/kg, intraperitoneally) and diclofenac
sodium (10 mg/kg, intraperitoneally). While the control group was expecting deionized
water, MEDM was given orally at dosages of 200, 400, and 600 mg/kg (0.1
mL/mouse, orally). Results: According to the current research, MEDM
strongly reflected the antinociceptive activity of all mouse models of chemical
and heat-induced pain (*p Conclusions: It is evident that the plant extract
has exceptional analgesic properties. To determine the precise processes behind
antinociceptive effect and to identify the substances that produce this
activity, more research is required. The study’s findings also support the
long-standing use of MEDM in painful conditions.