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V. W. Henderson, A. Paganini-Hill, B. L. Miller, R. J. Elble, P. F. Reyes, D. Shoupe, C. A. Mccleary, R. A. Klein, A. M. Hake and M. R. Farlow, “Estrogen for Alzheimer’s Disease in Women, Randomised Double-Blind, Placebo-Controlled Trial,” Neurology, Vol. 54, 2000, pp. 295-301.

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• TITLE: The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies

  AUTHORS: Peter K. Panegyres, Emily R. Atkins

  KEYWORDS: Amyloid Precursor Protein, APP, Genes, Dementia, Alzheimer’s Disease

  JOURNAL NAME: Neuroscience and Medicine, Vol.2 No.4, December 2, 2011

  ABSTRACT: Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.